If You Could Re-purpose Existing Biology, What Would You Make?
Through this blog I am exploring how naturally-occurring molecules can be re-purposed to create new biology, particularly in the discovery of new medicines. I’m doing all this with the eyes of an artist - looking into the nuts and bolts of making using biology, as well as examining the ethics of whether we should be tinkering with biology, and what this says about us as humans.
If you’d like to read more, start with my primer on Synthetic Biology, published by the Biochemical Society.
Cone Snails and Disulphide Bonds
Animal venom is packed with disulphide-rich peptides, but why? Is the toxicity caused by cysteine or is it something else?
Treating Chronic Pain With Pufferfish Poison
Pufferfish harbour a poison more deadly than cyanide, yet in low doses this toxin could help to ease chronic pain.
Keeping the Blood Flowing
Some venomous creatures interfere with the blood of their prey to ensure a good feed or to stop them in their tracks. Many of the molecules in their venom inspired the development of blood thinners used to prevent or break down blood clots.
Finding a Solid Foundation
A reflective post about honing ideas and deciding on a way forward.
Re-engineering Bacteria to Treat Diabetes
Our bodies’ natural bacteria could be re-engineered to fight disease.
It All Started With a Bite from the Gila Monster
The GLP-1 group of diabetes and obesity drugs are predicted to be worth over $100 bn by 2030. Yet, the first GLP-1 agonist was isolated from Gila monster venom.
Glow Worms: Not Just a Collection of Pretty Twinkling Lights
Glow worms inject venom to immobilise and then liquefy their prey.
So How Do You Make a Protein?
Thinking about making protein therapeutics? Why not harvest them from the cups of carnivorous plants?
Jellyfish and the Therapeutic Potential of Collagen
Collagen from jellyfish can be used to treat arthritis and help wounds heal faster.
It’s OK, Corn Snakes Aren’t Venomous
Corn snakes aren’t venomous but pit vipers are. Pit viper venom was the surprising source of the first anti-hypertensive medication, captopril.
Hello World
My journey from art to science started with a job scooping live crickets into tubs sold in exotic pet shops.
Please note: I’m a scientist with a PhD, not a medical doctor, and although I write about medicines, the information on this blog should not be misconstrued as medical advice. If you’re looking for medical advice, please speak to your GP or other medical care provider.